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Mulig nedsatt konsentrasjon av paracetamol, usikkert hvorvidt konsentrasjonen av den levertoksiske metabolitten NAPQI øker. Generelt sett er rifampicin den kraftigste induktoren, deretter kommer rifapentin, mens rifabutin er den svakeste induktoren av de tre. Som et eksempel er det vist at konsentrasjonen av indinavir reduseres med ca.

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Codeine is secreted into human milk. The maternal usage of codeine can possibly bring on significant adverse reactions, like Dying, in nursing infants .

to obtain at that value, as well as request sizing is the number of shares presented available for purchase at that value. The data displayed inside the estimate bar updates just about every 3 seconds; letting you to watch rates in true-time.

Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.

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Ammende skal ikke bruke kodeinholdige preparater sammenhengende utover two–3 dager. Diebarn bør observeres med tanke på slapphet og sedasjon. Kvinner med ultrarask genotype av CYP2D6 vil i høy grad kunne omdanne kodein til morfin.

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Sykelig forandring av leveren der det dannes bindevev i stedet for leverceller, slik at leverfunksjonen ødelegges.

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EMA ble opprettet i 1995 for å sikre best mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.

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